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Eyes can reveal onset of Alzheimer’s disease

Eyes can reveal onset of Alzheimer’s disease

New York: In a breakthrough research, US scientists have identified that early signs of Alzheimer’s disease can be detected by looking at the back of patients’ eyes.

The researchers found that the retina tissue shows evidence of toxic tau and inflammation — crucial for the onset of the neurodegenerative disease.

“Using the retina for detecting Alzheimer’s disease and other neurodegenerative diseases would be non-invasive, inexpensive and could become a part of a normal screening done at patient checkups,” said lead author Ashley Nilson, graduate student at The University of Texas Medical Branch at Galveston.

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The study demonstrated that the toxic tau, which spreads between connected brain regions, may initiate inflammation in brain regions.

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In Alzheimer’s, the tau protein changes into a toxic form called tau oligomers and begins clumping into neurofibrillary tangles, which can leading to the eventual death of the brain cells.

“Our findings suggest that the degeneration of nerve cells due to chronic inflammation induced by the tau oligomers may be combated through the combination of anti-tau oligomer and anti-inflammatory therapeutics for the treatment of Alzheimer’s and related diseases,” added Rakez Kayed, Associate Professor at The University of Texas Medical Branch.

This situation can create a cycle of toxic tau, inflammation and cell death throughout the brain over time.

For the study, the team performed a systematic analyses of brain and retina samples from people with Alzheimer’s and a mouse model of Alzheimer’s.

“Early detection of Alzheimer’s warning signs would allow for early intervention and prevention of neuro-degeneration before major brain cell loss and cognitive decline occurs,” Nilson said.

Beyond determining eye health and corrective lens prescriptions, having an eye exam can alert health care professionals of several different health conditions including diabetic complications, high cholesterol and high blood pressure, the researchers suggested, in the paper in the Journal of Alzheimer’s Disease.

Source: IANS

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  1. user
    Dr Ramesh Vardhan November 23, 2016, 12:13 pm

    That\’s why EYE is called the Window Of Mind . Unfortunately HARDLY any Doctor in India , except some of The Eye surgeons, use the ophthalmoscope to see/ visualize the Retina. Despite this is being simples of the simple, coast effective and time saving hardly any body uses it. Instead Majority of the Praticeners ( I call them Qualified Quacks). Refer the innocent patients for CT scan/ MRI scan even with out knowing how to interpret , for their personal gain. Which requires the REAL surgical strike. There should be should be some investigating body to check the wrong doings by such Greedy Praticeners. The state MCI bodies are of no use except for Registration of newly passed out graduates. The MCI apex body should send it\’s TEAM of experts to inspect the Hospitals across the country as done in the case of Medical colleges alone. The hospital also be inspected by one or other experts central Agencies.

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