EEG may predict treatment response in Anxiety/ Depression
- At baseline, higher levels of depressive symptoms were associated with a more attenuated RewP.
- There were no significant differences between patients and healthy controls in the degree of RewP change across the 12 weeks; however, among patients, the extent of increase in RewP robustly correlated with the extent of decline in depressive and anxiety symptoms following CBT and SSRI treatment.
- A more attenuated RewP at baseline predicted a greater reduction in depressive symptoms following treatment with SSRIs, but not after CBT.
"There are serious considerations that go into prescribing either of these treatments," Burkhouse said. "SSRIs can have unwanted side effects, while CBT requires a significant amount of time and commitment, and practitioners trained in delivering CBT can be hard to find and those that practice this form of therapy may be booked and not able to take on new patients."
"These findings could help bring precision medicine closer to reality for patients with anxiety and depressive disorders," said Dr. K. Luan Phan, professor of psychiatry in the UIC College of Medicine and a senior author on the paper.
Many patients who seek treatment for their anxiety and depression don't always do well with the first therapy prescribed due to not being able to tolerate side effects of drugs or not being able to commit to weeks of talk therapy, said Phan.
"These findings highlight neural responsiveness to reward as both a mechanism and a predictor of depressive symptom change that may be used to serve as an objective index of symptom improvement," concluded the authors.