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Consumption of diet soda linked to diabetic retinopathy


Consumption of diet soda linked to diabetic retinopathy

Singapore: It is a surprise Finding! Diet soda, not sugary soft drinks linked to diabetic retinopathy. Consumption of more than 4 cans of diet soda (1.5 L) per week is associated with a more than twofold risk of proliferative diabetic retinopathy (PDR) in diabetic patients, according to a new study published in the journal Clinical and Experimental Ophthalmology. PDR is a severe type of diabetic eye disease that can lead to blindness. This finding was independent of traditional risk factors for diabetic retinopathy, including diabetes control parameters and duration of diabetes.

Drinking soft drink has long been associated with an increased risk of cardiovascular disease. To address the health consequences associated with the consumption of soft drinks, artificially sweetened ‘diet’ soft drinks, due to their lack of sugar, have been marketed as a healthier alternative. However, several recent studies have linked diet soft drinks with poor cardiovascular outcomes. 
Therefore, Eva K Fenwick, Singapore Eye Research Institute (SERI), Singapore National Eye Centre, Singapore, and colleagues conducted this cross-sectional study to explore the association between regular and diet soft drink consumption, and DR and diabetic macular edema (DME).

The study is the first to evaluate the link between soft drink consumption and microvascular complications of diabetes.

The study evaluated a total of 609 adults; 73 had type 1 diabetes and 510 had type 2 diabetes, and 26 had unknown diabetes type, at a tertiary eye hospital between 2009 and 2010. The mean age of the participants was 64.6 years. They came from the Diabetes Management Project, a cross-sectional study of English-speaking adults with diabetes in Melbourne, Australia.

Participants underwent objective measurement of diabetic retinopathy and diabetic macular edema with standardized techniques to determine how soft drinks may affect microvascular complications of diabetes.

Participants self-reported soft drink consumption on a 145-question food frequency questionnaire. Of the total sample, 285 participants (46.8%) drank regular soft drinks, and 190 (31.2%) drank diet soft drinks.

Key Findings:

  • Almost 146 participants (24%) had proliferative diabetic retinopathy.
  • A total of 230 (37.8%), 36 (5.9%), 154 (25.3%), 28 (4.6%) and 146 (24.0%) had no DR, mild non-
    proliferative DR (NPDR), moderate NPDR, severe NPDR and proliferative DR (PDR), respectively.
  • High diet soft drink consumption was independently associated with an increased likelihood of having PDR, compared to no consumption.
  • In contrast, the regular, sugar-sweetened soft drinks was not associated with DR or DME. 

The last result is consistent with past research, note the researchers. Some studies have found a link between consumption of diet soft drinks, but not regular soft drinks, and vascular complications of diabetes. Others have failed to confirm these findings. The authors mention several explanations for this discrepancy.

“Our finding that regular soft drink was not associated with increased risk of proliferative diabetic retinopathy could be due to the small numbers of high consumers. We had to merge the high-consumer category with the moderate-consumer category, and this may have masked the true relationship,” Fenwick told Medscape Medical News.

“Although the results of our study must be interpreted within the context of several limitations, they add to the growing body of literature on the harmful effects of diet drinks on a range of health outcomes, including CVD [cardiovascular disease], diabetes, and metabolic syndrome,” Fenwick said.

Because the study was cross-sectional, further longitudinal studies are needed to determine whether soft drinks are unhealthy alternatives to sugar-sweetened beverages, she added.

“Given that diet soft drinks are perceived as a healthy alternative to regular soft drinks, clinicians and patients should be aware that diet soft drinks may not be without risks of their own,” she concluded.

For further reference follow the link: 10.1111/ceo.13154

Source: With inputs from Clinical and Experimental Ophthalmology

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