This site is intended for Healthcare professionals only.

Common Viral Infection Could Give You Constipation


Common Viral Infection Could Give You Constipation

New York : Offering a ray of hope for people with unexplained chronic constipation, researchers have shown a surprising link between constipation and herpes infection.

Individuals with herpes have reported seemingly unrelated symptoms such as constipation and urinary retention (inability to empty the bladder), but the mechanism was not understood.

So the research team decided to investigate using mice models of herpes simplex virus-1, the dominant cause of genital herpes in the US.

They found that the herpes virus spread from the genitals to nerves in the spinal chord, and then on to neurons in the colon, killing them.

The damage to the colonic neurons prevented the movement of food along the digestive tract, leading to an enlarged colon and disease.

While the effects in mice are distinct from what happens in people with herpes, the study reveals a previously unrecognised disease process.

“The key findings is that there is this unexpected infection in the neurons in the colon wall after herpes infection,” said lead researcher Akiko Iwasaki, professor of immuno biology at Yale School of Medicine in New Haven, Connecticut, US.

The findings were published in the journal Cell Host & Microbe.

“Other members of the herpes virus family, including Epstein-Barr virus, chicken pox virus, and cytomegalovirus have been found in the neurons of the colon of people with unexplained chronic constipation,” Iwasaki, who is also an investigator at Maryland-based non-profit Howard Hughes Medical Institute, said.

“When doctors can’t figure out the cause of these chronic intestinal conditions, one thing to look at is a viral infection,” she explained.

The following two tabs change content below.
supriya kashyap

supriya kashyap

Supriya Kashyap Joined Medical Dialogue as Reporter in 2015 . she covers all the medical specialty news in different medical categories. She also covers the Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in medical filed. She is a graduate from Delhi University. She can be contacted at supriya.kashyap@medicaldialogues.in Contact no. 011-43720751
Source: self

Share your Opinion Disclaimer

Sort by: Newest | Oldest | Most Voted