Catheter ablation may improve outcomes in patients with atrial fibrillation and heart failure revealed a study published in the European Heart Journal. The study compared the efficacy of different rhythm control strategies in patients with atrial fibrillation and heart failure.
Atrial fibrillation and heart failure management remain a challenge for cardiologists. Prior studies have proposed enhanced outcomes after catheter ablation as compared to conventional drug therapy alone in patients with heart failure (HF) and atrial fibrillation (AF).
A team of scientists at the Frankfurt Academy For Arrhythmias sought to evaluate the efficacy and safety of rhythm control strategy in patients with AF complicated with HF regarding hard clinical endpoints. Up-to-date randomized data comparing rhythm control using antiarrhythmic drugs (AADs) vs. rate control (Subset A) or rhythm control using catheter ablation vs. medical therapy (Subset B) in AF and HF patients were pooled.
The primary outcomes were all-cause mortality, re-hospitalization, stroke, and thromboembolic events. A total of 11 studies involving 3598 patients were enrolled.
As compared with medical rate control, the AADs rhythm control was associated with similar all-cause mortality, A significantly higher rate of re-hospitalization, and a similar rate of stroke and thromboembolic events
As compared with medical therapy, catheter ablation rhythm control was associated with significantly lower all-cause mortality, reduced re-hospitalization rate, a similar rate of stroke events, greater improvement in left ventricular ejection fraction, lower arrhythmia recurrence, and greater improvement in the quality of life.
Based on the results the authors concluded that ” Catheter ablation as rhythm control strategy substantially improves survival rate, reduces re-hospitalization, increases the maintenance rate of sinus rhythm, contributes to preserving cardiac function, and improves quality of life for AF patients complicated with HF.”
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