Bones of children maturing earlier now, finds a new study

According to a new study from the University of Missouri School of Medicine appearing in the Journal Clinical Orthopaedics and Related Research Children born in the most recent century have bones that reach full maturity earlier by nearly 10 months in girls and nearly seven months in boys.

Epiphyseal fusion (EF) marks the completion of longitudinal bone growth, a critical milestone monitored during treatment of skeletal growth and/or developmental disorders. Recently, a trend toward accelerated skeletal maturation in children has been documented.

The research team, led by Duren, assessed the radiographs of more than 1,000 children born between 1915 and 2006. The team evaluated radiographs of the bones in the hands and wrists to determine the precise timing of the beginning and end of a developmental process called epiphyseal fusion. The results showed that the skeletons of children born in the 1990s are reaching fusion completion, and thus skeletal maturity, faster and sooner than children born in the 1930s.

“Our findings show there is a “new normal” for timing when kids’ skeletons will reach full maturity,” said Dana Duren, PhD, director of orthopaedic research at the Thompson Laboratory for Regenerative Orthopaedics. The research team, led by Duren, assessed the radiographs of more than 1,000 children born between 1915 and 2006. The team evaluated radiographs of the bones in the hands and wrists to determine the precise timing of the beginning and end of a developmental process called epiphyseal fusion.

“We focused on epiphyseal fusion because it signals the end of the growth of the bone,” said Duren, who was the principal investigator. “It begins when the growth plate, which is cartilage at the end of the bone, starts to connect the epiphysis, or bone cap, to the long bone through small calcifications. Eventually, the growth plate completely calcifies and attaches, or fuses, to the long bone. When fusion is complete, so is the growth of that bone.”

These findings directly impact the timing of the clinical care of certain pediatric orthopaedic conditions, such as leg-length differences, scoliosis and the timing of using growth hormone. Mel Boeyer, MS, predoctoral orthopaedic research fellow and co-author of the study, works closely with pediatric orthopaedic surgeons to understand how physicians time this care.

“The timing for the treatments of these conditions is a critical component to a good outcome,” said Boeyer. “What this research shows us is physicians will need to start looking for the beginning of epiphyseal fusion sooner than they once thought.” The study does not address what might be the cause of this new normal. However, Duren and many of her colleagues think an increase in exposure to environmental hormones and hormone mimickers could be a contributing factor.

For further reference log on to: DOI: 10.1097/CORR.0000000000000446