Blood thinning therapy not for female heart patients

Researchers noted the sex differences as they reviewed medical therapies for 1,585 patients whose doctors were testing a computerized decision support tool that uses patient information and characteristics to aid physicians and patients with decisions about anticoagulant therapy to prevent stroke in atrial fibrillation patients, explains Mark Eckman, MD, Posey Professor of Clinical Medicine and lead study investigator. Those enrolled in the trial were all patients in the UC Health primary care network.

The computerized model is known as the Atrial Fibrillation Decision Support Tool (AFDST) and is a decision analytic model integrated into UC Health's electronic health record. It pulls information about patients with atrial fibrillation and is able to calculate for the individual patient his or her risk of AF-related stroke and major bleeding while taking blood thinning therapy, says Eckman, a UC Health physician. Based on this information, the AFDST makes suggestions for the best treatment to prevent AF-related stroke.

Under treatment of patients with atrial fibrillation (AF) is a national problem and the AFDST is designed to get more Tristate AF patients using anticoagulants when appropriate, says Eckman, Director of the Division of General Internal Medicine at UC. The AFDST supports clinician decision-making by suggesting when blood thinning therapy is warranted. About 45 percent of women AF patients (326/725) were receiving potentially non-optimal treatment to prevent AF-related stroke (i.e., treatment that was different than that suggested by the AFDST), while only 39 percent of men with AF (338/860) were receiving discordant therapy, says Eckman.

"The irony is that women have a higher risk of AF-related stroke, controlling for other risk factors such as hypertension, diabetes, congestive heart failure, yet women are being under treated," said Eckman.

"There are some take home messages," says Eckman. "Doctors need to realize we have mental biases that women are healthier and at lower risk of stroke. It's the same story for coronary artery disease and risk of heart attacks. We think women are at lower risk and we ignore warning signs. Thus, when we are making decisions for blood thinning therapy for patients with atrial fibrillation, we need to remember that women are at higher risk and we need to make sure we treat them aggressively enough to prevent stroke."