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Azithromycin, levofloxacin, rifaximin all effective for travelers diarrhea
Three single-dose antibiotic regimens azithromycin, rifaximin and levofloxacin were all comparable for treating travelers’ diarrhea when paired with loperamide, according to findings recently published in Clinical Infectious Diseases.
Travelers’ diarrhea affects anywhere from 10% to 40% of short-term international travelers and recommended treatment for it includes the combination of an antibiotic, usually a fluoroquinolone or azithromycin, and loperamide for rapid resolution of symptoms. However, adverse events, postdose nausea with high-dose azithromycin, effectiveness of single-dose rifaximin, and emerging resistance to front-line agents are evidence gaps underlying current recommendations.
It was concluded that Single-dose azithromycin, levofloxacin, and rifaximin with loperamide were comparable for treatment of acute watery diarrhea."Overall, our findings provide strong evidence that loperamide-adjuncted, single-dose antibiotic therapy for [acute watery diarrhea] among travelers is safe and highly effective,” the researchers wrote. “Furthermore, these results highlight rapid clinically relevant improvement of illness and diarrheal symptoms associated with combination therapy.”
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