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Atopic dermatitis patients with low vitamin D highly sensitive to house dust mites


Atopic dermatitis patients with low vitamin D highly sensitive to house dust mites

The relationship between atopic dermatitis (AD) and low vitamin D levels has been studied and the findings, which are described as “significant,” but preliminary appear in the August print issue of the Annals of Dermatology. Emerging evidence has implicated vitamin D as a critical regulator of immunity, playing a role in both the innate and cell-mediated immune systems. Patients with severe atopic dermatitis who have lower serum vitamin D levels have a high sensitivity to house dust mites which can aggravate their condition, a new study shows.However, the effect of vitamin D on house dust mite (HDM) sensitization in patients with AD has not been established.

The investigators  studied 80 patients in total with only 43 men and 37 women of which 43.8% had mild to moderate disease and 56% had severe atopic dermatitis, which was determined by Rajka and Langeland scores. Laboratory tests included serum 25-hydroxyvitamin D3, total immunoglobulin E (IgE), and specific IgE antibody titer against Dermatophagoides farinae and D pteronyssinus.

It was found that there  were no differences in vitamin D levels between the mild or moderate AD and severe AD groups. In the severe AD group, high HDM sensitization group had lower serum vitamin D levels compared to low HDM sensitization group with statistical significance. In addition, a significant negative correlation was found between vitamin D levels and HDM sensitization in the severe AD group. The mean serum vitamin D level of patients in the study was 19.29±8.03 ng/ml. There was no significant difference between serum vitamin D levels between patients with severe AD (19.46±8.10 ng/ml) and mild to moderate AD (18.98±7.97 ng/ml, p=0.72). But for patients with severe atopic dermatitis, the mean total serum IgE level (2,011.96± 993.89 kU/L) was significantly higher than that in patients with mild to moderate AD (260.88±431.54 kU/L, p<0.05).

Patients with severe atopic dermatitis who had significantly lower serum vitamin D levels were also found to have high D. farina sensitization (p<0.05). The same was true of D. pteronyssinus in which patients with severe disease, the presence of high D. pteronyssinus sensitization usually equated with lower serum vitamin D levels with statistical significance (p<0.05). No such association was found in mild to moderate disease.

  It was therefore concluded that low vitamin D levels may link to high HDM sensitization in patients with the severe Atopic Dermatitis. Further elucidation of the role of vitamin D in HDM sensitization may hold profound implications for the prevention and treatment of AD. In conclusion, our results demonstrate that low vitamin D levels may be relevant to high HDM sensitization in severe AD patients. Further investigation regarding the effect of vitamin D in HDM sensitization can give new strategies for the prevention and treatment of AD. We also need the refinement and modification of large-scale studies to determine the relationship between serum vitamin D levels and HDM sensitization in AD.

For more details click on the link : Yong Hyun Jang, Hyun Bo Sim, Sun Young Moon, Weon Ju Lee, Seok-Jong Lee, Meiling Jin1, Sang-Hyun Kim1, Do Won Kim. “House Dust Mite Sensitization Is Inversely Associated with Plasma 25-Hydroxyvitamin D3 Levels in Patients with Severe Atopic Dermatitis,” Annals of Dermatology. August 2017. https://doi.org/10.5021/ad.2017.29.4.400 

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Anjali Nimesh

Anjali Nimesh

Anjali Nimesh Joined Medical Dialogue as Reporter in 2016. she covers all the medical specialty news in different medical categories. She also covers the Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in medical filed. She is a graduate from Dr. Bhimrao Ambedkar University. She can be contacted at editorial@medicaldialogues.in Contact no. 011-43720751
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