Probiotics often called “good” or “helpful” bacteria and hailed as the cure for many digestive ailments due to their ability to boost the digestive health may not be as beneficial as we think it to be, suggests two back-to-back reports published in the journal Cell. The researchers at the Weizmann Institute of Science show — in both mice and in humans — that a probiotic preparation of 11 strains of the most widely used probiotic families may sometimes be less-than-beneficial for the user and their microbiome.
These studies are significant as nowadays, in a bid to improve their overall health many people are taking probiotics — preparations containing live bacteria that are meant to fortify their immune systems, prevent disease or repair the adverse effects of antibiotics. However, the benefits of taking probiotics have not been medically proven yet. It is not even clear if probiotic bacteria really colonize the digestive tract or, if they do, what effects these have on humans and their microbiomes – the native bacteria in their guts.
For the first study, 25 human volunteers underwent upper endoscopy and colonoscopy to sample their baseline microbiome composition and function in different gut regions. Fifteen of those volunteers were then divided into two groups: The first was administered the 11-strain probiotic preparation, and the second was given placebo pills. Three weeks into the four-week treatment, all participants underwent a second upper endoscopy and colonoscopy to assess their response to the probiotics or placebo, and they were then followed for an additional two months.
Key Findings of the First Study:
- Probiotics’ gut colonization was highly individual.
- gut colonization of probiotics fell into two main groups: The “persisters” guts hosted the probiotic microbes while the microbiomes of “resisters” expelled them.
- The team found they could predict whether a person would be a persister or resister just by examining their baseline microbiome and host gene expression profile.
- Persisters exhibited changes to their native microbiome and gut gene expression profile, while resisters did not have such changes.
The researchers discovered that probiotics’ gut colonization was highly individual. However, they fell into two main groups: The “persisters” guts hosted the probiotic microbes while the microbiomes of “resisters” expelled them. The team found they could predict whether a person would be a persister or resister just by examining their baseline microbiome and host gene expression profile. Persisters, they noted, exhibited changes to their native microbiome and gut gene expression profile, while resisters did not have such changes.
The studies were conducted by Eran Elinav, professor, Immunology Department, Weizmann Institute of Science, Rehovot, Israel, in collaboration with Zamir Halpern, Director of the Gastroenterology Division Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
“Our results suggest that probiotics should not be universally given to the public as a ‘one size fits all’ supplement,” says Elinav. “Instead, they could be tailored to each individual and their particular needs. Our findings even suggest how such personalization might be carried out.
In the second study, the researchers addressed a related question that is of equal importance to the general public, who are often told to take probiotics to counter the effects of antibiotics: Do probiotics colonize the gut following antibiotic treatment, and how does this impact the human host and their microbiome?
The researchers administered wide-spectrum antibiotics to 21 human volunteers, who then underwent an upper endoscopy and colonoscopy to observe the changes to both the gut and its microbiome following the antibiotic treatment. Next, the volunteers were randomly assigned to one of three groups. The first was a “watch and wait” group, letting their microbiome recover on its own. The second group was administered the 11-strain probiotic preparation over a four-week period. The third group was treated with an autologous fecal microbiome transplant (aFMT), made up of their own bacteria that had been collected before giving them the antibiotic.
- Probiotics, after the antibiotic had cleared the path, could easily colonize the human gut – more so than in the previous study in which antibiotics had not been given.
- To the team’s surprise, the probiotics’ gut colonization prevented both the host gut’s gene expression and their microbiome from returning to their normal pre-antibiotic configurations for months afterward.
- In contrast, autologous FMT resulted in the native gut microbiome recolonizing and the gut gene expression profile returning to normal within days.
“These results,” says Elinav, “reveal a new and potentially alarming adverse side effect of probiotic use with antibiotics that might even bring long-term consequences. In contrast, personalized treatment — replenishing the gut with one’s own microbes — was associated with a full reversal of the drugs’ effects.”
Since probiotics are among the world’s most traded over-the-counter supplements, these results may have immediate, broad implications. “Contrary to the current dogma that probiotics are harmless and benefit everyone,” says Eran Segal, professor, Weizmann Institute of Science. “we suggest that probiotics preparations should be tailored to individuals, or that such treatments such as autologous FMT may be indicated in some cases.”
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