Antidiabetics improve cognitive function in Alzheimer’s Disease

A new study published in the journal Plos One reveals that antidiabetic medications may have beneficial effects on cognitive function and on Alzheimer’s disease-related neuropathology.

The results suggested that anti-diabetes medications had a protective effect on the brains of Alzheimer’s disease patients.

According to Mount Sinai researchers, this is the first study to examine what happens in the pathways of both brain tissue and endothelial cells—the cells lining blood vessels—in the brains of Alzheimer’s patients treated with diabetes medication.

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The results of the study will inform future Alzheimer’s disease studies and potential new therapies targeting specific cells since they suggest that targeting the brain’s capillary system could have beneficial effects in Alzheimer’s patients.

“Most modern Alzheimer’s treatments target amyloid plaques and haven’t succeeded in effectively treating the disease,” said Dr. Haroutunia, co-author of the study. “Insulin and diabetes medications such as metformin are FDA approved and safely administered to millions of people and appear to have a beneficial effect on people with Alzheimer’s. This opens opportunities to conduct research trials on people using similar drugs or on drugs that have similar effects on the brains’ biological pathways and cell types identified in this study.”

In order to have a molecular level study, Mount Sinai research team developed a method to separate brain capillaries from the brain tissue of 34 people with Alzheimer’s and type 2 diabetes who had been treated with anti-diabetes drugs and compare them to tissue from 30 brains of people with Alzheimer’s without diabetes and 19 brains of people without Alzheimer’s or diabetes. (Because most people who have diabetes are treated with insulin or oral medications, the scientists were unable to compare their results to brain tissue from people with Alzheimer’s disease and diabetes who were not treated with anti-diabetes drugs.)

Then, they examined the vessels and brain tissue separately to measure Alzheimer’s Disease-associated changes in molecular RNA markers for brain capillary cells and insulin signaling.

The researchers found that the levels of about half of these markers were reduced in the vessels and brain tissue in the group with Alzheimer’s and diabetes. The great majority of the RNA changes seen in Alzheimer’s disease were absent in those Alzheimer’s patients who had been treated with anti-diabetes drugs.

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“The results of this study are important because they give us new insights for the treatment of Alzheimer’s disease,” said the study’s senior author, Vahram Haroutunian, Ph.D., Professor of Psychiatry and Neuroscience at the Icahn School of Medicine at Mount Sinai.

For full study log on to https://doi.org/10.1371/journal.pone.0206547