Silent Killer! Anabolic-androgenic steroid use associated with ventricular dysfunction in weightlifters: ESC 2019 Update

Paris, France: Anabolic-androgenic steroid use is associated with a number of worrying effects on the heart that may lead to ventricular dysfunction in weightlifters, revealed a study presented at the ESC Congress 2019 together with the World Congress of Cardiology.

The study presented at the conference showed that illicit performance-enhancing steroids can cause the heart to thicken and reduce its ability to function.

"Our study found that illicit steroid use is associated with a number of worrying effects on the heart. We demonstrated that AAS-using weightlifters have a thicker heart muscle and reduced ability to contract the ventricular chambers of the heart during a cardiac cycle," said Rang Abdullah, a third-year medical student at the University of Oslo, Norway.

"Having a heart that doesn't contract the way it should is associated with higher mortality," he added.

Use of anabolic-androgenic steroids (AAS) has long been feared to have hazardous cardiovascular effects, but only recently has this been demonstrated in studies.

The study presented today examined the effects of long-term AAS use on left ventricular systolic function by assessing the size, thickness, mass, and function of the heart in male weightlifters.

The study is part of a large multidisciplinary study on AAS use, which includes studies on brain imaging, cognitive, psychological, and other cardiovascular functions.

Study authors recruited 100 male weightlifters - 58 with more than a year of cumulative AAS use and 42 who do not use steroids - with no difference in age or BMI between the two groups.

The size, thickness, mass, and function of the heart were measured with echocardiography, which uses sound waves to monitor heart and valve function, and ejection fraction, which measures how much blood the left ventricle pumps out with each contraction.

AAS-using weightlifters had a thicker heart muscle - on average, a 2 mm thicker interventricular septum, which is the wall separating the lower chambers of the heart. The left ventricular posterior wall was also, on average, 1.2 mm thicker in the steroid group.

The steroid group also showed reduced ability to contract the ventricular chambers of the heart during a cardiac cycle. Both ejection fraction and ventricular global strain, a new method to assess systolic function, were decreased in AAS-exposed weightlifters as compared to the non-steroid group, 49% vs. 53%, on average, and -15.6% vs. -18.3%.

Abdullah said, surprisingly, only a minority of steroid users in the sample had experienced cardiovascular symptoms related to their AAS use.

"There are many case studies out there on AAS-using weightlifters who end up dead or hospitalized from a heart attack or life-threatening cardiac arrhythmias. This is why prospective observational trials on this subject are so desperately needed," he concluded.