An effective, Safe Combo Therapy for Severe Inflammatory Acne
They found that treatment with the combination gel + oral doxycycline was associated with a 66.2% reduction in inflammatory lesions, a 58.7% reduction in non-inflammatory lesions, and a 62.6% reduction in total lesions at Week 12 vs baseline. Moreover, 37.1% of patients achieved Investigator's Global Assessment (IGA) success (defined as IGA 0 [clear] or 1 [almost clear]).
At the end of the treatment period, 80.1% of patients were no longer considered candidates for OI. Most of the study patients (90.2%) reported at least moderate improvement in acne vulgaris (AV) (90.2%); 83.2% said they were "satisifed" or "very satisfied" with the combination treatment overall. Skin burning sensation and erythema were the most common treatment-emergent adverse events (AEs) reported.
The authors concluded that "[Adapalene/benzoyl peroxide gel 0.3%/2.5% plus doxycycline] is an effective and safe treatment option for severe inflammatory AV, before starting oral isotretinoin OI treatment, or as an alternative when OI cannot be used".
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