Exercise may increase grey matter volume and slow cognitive decline, finds study

ROCHESTER, Minn. -- Cardiorespiratory exercises including walking briskly, running, biking and just about any other exercise are good for the body, but can they also slow cognitive changes in the brain? Brain tissue is made up of grey matter, or cell bodies, and filaments, called white matter, that extend from the cells. The volume of grey matter appears to correlate with various skills and cognitive abilities.

Researchers at German Center for Neurodegenerative Diseases have found an association between cardiorespiratory fitness and brain health, particularly in grey matter and total brain volume -- regions of the brain involved with cognitive decline and ageing. The researchers found that increases in peak oxygen uptake were strongly associated with increased grey matter volume. The study has been published in Mayo Clinic Proceedings.

The study involved 2,013 adults from two independent cohorts in northeastern Germany. Participants were examined in phases from 1997 through 2012. Cardiorespiratory fitness was measured using peak oxygen uptake and other standards while participants used an exercise bike. MRI brain data also were analyzed.

The results suggest cardiorespiratory exercise may contribute to improved brain health and decelerate a decline in grey matter. An editorial by three Mayo Clinic experts that accompanies the Mayo Clinic Proceedings study says the results are "encouraging, intriguing and contribute to the growing literature relating to exercise and brain health."

Ronald Petersen, M.D., Ph.D., a Mayo Clinic neurologist and first author of the editorial, says the most striking feature of the study is the measured effect of exercise on brain structures involved in cognition, rather than motor function. "This provides indirect evidence that aerobic exercise can have a positive impact on cognitive function in addition to physical conditioning," he says. "Another important feature of the study is that these results may apply to older adults, as well. There is good evidence for the value of exercise in midlife, but it is encouraging that there can be positive effects on the brain in later life as well."

Dr. Petersen is the Cora Kanow Professor of Alzheimer's Disease Research and the

Chester and Debbie Cadieux Director of the Mayo Clinic Alzheimer's Disease Research Center.

The study's finding of higher gray matter volume associated with cardiorespiratory exercise are in brain regions clinically relevant for cognitive changes in aging, including some involved in Alzheimer's disease. The editorial calls those associations interesting but cautions against concluding that cardiorespiratory fitness correlations would affect Alzheimer's disease.

"This is another piece of the puzzle showing physical activity and physical fitness is protective against aging-related cognitive decline," says Michael Joyner, M.D., a Mayo Clinic anesthesiologist and physiologist, and editorial co-author. "There's already good epidemiological evidence for this, as well as emerging data showing that physical activity and fitness are associated with improved brain blood vessel function. This paper is important because of the volumetric data showing an effect on brain structure."

Dr. Joyner is the Frank R. and Shari Caywood Professor at Mayo Clinic.

Long-term studies on the relationship between exercise and brain health are needed, which will be costly and logistically challenging to produce. "Nevertheless, these data are encouraging," says Clifford Jack Jr., M.D., a Mayo Clinic neuroradiologist and co-author of the editorial. "The findings regarding cardiorespiratory fitness and certain brain structures are unique."

Dr. Jack is the Alexander Family Professor of Alzheimer's Disease Research.

According to Mayo Clinic experts, moderate and regular exercise -- about 150 minutes per week -- is recommended. Good cardiorespiratory fitness also involves:

Not smoking

Following healthy eating habits

Losing weight or maintaining a healthy weight level

Managing blood pressure and avoiding hypertension

Controlling cholesterol levels

Reducing blood sugar, which over time can damage your heart and other organs

University Medicine Greifswald, Germany, also was part of the research project. Katharina Wittfeld, Ph.D., a researcher at the German Center for Neurodegenerative Disease, is the first author.

Mayo Clinic Proceedings