A closer look at osteoporosis medications mechanisms may improve outcomes

New findings from Henry Kronenberg's lab at Massachusetts General Hospital and Harvard Medical School suggest that while teriperatide treatment does increase the proliferation of osteoblasts, stopping treatment may have adverse effects. A study published this week in the JCI reports that the number of osteoblast precursor cells and their mature descendants increased in mice undergoing teriparatide treatment. When mice were withdrawn from teriparatide treatment, not only did osteoblast proliferation diminish, but the number of newly-formed fat cells, or adipocytes, increased.

These findings suggest that therapies targeting the parathyroid hormone receptor may enhance osteoblast populations by prioritizing osteoblast development over other cell fates, including adipocytes. The findings also offer insights into possible drawbacks of teriparatide therapy, indicating that the long-term consequences of brief treatment periods could outweigh the benefits.

For more details click on the link : Deepak H. Balani, Noriaki Ono, Henry M. Kronenberg. Parathyroid hormone regulates fates of murine osteoblast precursors in vivo. Journal of Clinical Investigation, 2017; DOI: 10.1172/JCI91699