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Air pollution may lead to Infertility, finds study

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Air pollution may lead to Infertility, finds study

Air pollution may lead to reduced sperm production and infertility, finds a study.

New research suggests that exposure to tiny air pollution particles may lead to reduced sperm production. The findings of the study have been presented at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.

The World Health Organization (WHO) estimates that approximately 15 per cent of the global population has difficulty with fertility, and male infertility accounts for about half of those problems.

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There are numerous factors that can impact fertility, and sadly pollution or severe smog is included on the list of reasons.  Fertility specialists know how to help patients when conception is impeded due to medical challenges, such as tubal disease, sperm factors, egg factors, etc.  Yet, there is little physicians can offer preventively when the problem is environmental – such as in the case of severe pollution.

“Infertility rates are increasing around the world, and air pollution may be one of the main factors,” said lead researcher Elaine Maria Frade Costa, M.D., Ph.D., of Sao Paulo University in Sao Paulo, Brazil.

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The study looked at the effect of particulate matter (PM) on sperm production. PM is a mixture of solid particles and liquid droplets found in the air. PM2.5 is a fine inhalable particle with diameters that are 2.5 micrometres or smaller. The average human hair is about 70 micrometres in diameters, making it 30 times larger than the biggest fine particle. PM2.5 is known to disrupt the endocrine system in humans and animals. The endocrine system is involved in reproduction, including the production of sperm.

The study included four groups of mice. One was exposed to PM2.5 from Sao Paolo before and after birth, from the day they were weaned from their mother’s milk until adulthood. The second group was exposed only during gestation. The third group was exposed after birth from weaning until adulthood, and the fourth group was exposed only to filtered air during gestation and from the time they were weaned until adulthood.

The researchers analyzed the testes of the mice and their production of sperm. DNA tests were used to evaluate gene expression, the process by which genes in DNA provide instructions for proteins.

The tubes in the testes that produce sperm of all the exposed mice showed signs of deterioration. In comparison with the mice not exposed to PM2.5, the sperm of the first group, which was exposed before and after birth, was of significantly worse quality.

The exposure to PM2.5 led to changes in the levels of genes related to testicular cell function. Exposure to PM2.5 after birth seemed to be the most harmful to testicular function, the study found.

Costa said these changes are epigenetic, which means they are not caused by changes in the DNA sequence. Epigenetic changes can switch genes on or off and determine which proteins a gene expresses.

The research demonstrates for the first time that exposure to air pollution of a large city impairs production of sperm through epigenetics, mainly in exposure after birth, Costa said. “These findings provide more evidence that governments need to implement public policies to control air pollution in big cities,” she said.




Source: self

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