A cancer drug may reduce painful symptoms in Endometriosis, study suggests
Endometriosis is a painful chronic condition which affects 176 million women worldwide. It is caused by the growth of lesions made up of tissue similar to the lining of the womb in other parts of the body, such as the lining of the pelvis and ovaries.
Researchers from the University of Edinburgh have found that the painful symptoms of Endometriosis could potentially be reduced with a drug that had previously been investigated as a cancer treatment. They found that using dichloroacetate to treat the cells of women with endometriosis lowered the production of lactate - a potentially harmful waste product - and stopped abnormal cell growth.
The research further revealed that the cells from the pelvic wall of women with endometriosis have different metabolism compared to women without the disease. The cells produced higher amounts of lactate similar to the behaviour of cancer cells. This research is published in the Proceedings of the National Academy of Sciences.
When the cells from women with endometriosis were treated with dichloroacetate, they were found to return to normal metabolic behaviour. The scientists also noted a reduction in lactate and an impact on the growth of endometrial cells grown together with the pelvic cells.
Further tests on a mouse model of endometriosis found, after seven days, a marked reduction in lactate concentrations and the size of lesions.
This research was funded by the charity Wellbeing of Women, and supported by PwC and the Medical Research Council UK.
Currently available treatments for endometriosis are either hormone-based, which can produce unpleasant side effects, or surgery, which is half of the cases, results in lesions returning after five years.
The researchers believe these new findings could help alleviate endometriosis in women who cannot - or do not wish to - take hormonal treatments or prevent recurrence after surgery. The team are conducting an early-phase clinical trial to confirm their findings.
The wellbeing of Women aims to saves and transforms the lives of women and gives babies the best start in life by finding cures and treatments across the breadth of female reproductive health, including overlooked areas like endometriosis.
Lead Researcher, Professor Andrew Horne, MRC Centre for Reproductive Health at the University of Edinburgh, said: "Endometriosis can be a life-changing condition for so many women. Now that we understand better the metabolism of the cells in women that have endometriosis, we can work to develop a non-hormonal treatment. Through a clinical trial with dichloroacetate, we should be able to see if the conditions we observed in the lab are replicated in women."
Janet Lindsay, CEO of Wellbeing of Women said: "More than 176 million women suffer from endometriosis yet few people have heard of it and treatment, which can impact fertility, has progressed very little for over 40 years. This is why we are so excited by the findings of this research that the Wellbeing of Women has funded and which could lay the basis for the first new non-hormonal treatment offering women a life-changing option. We are delighted that Professor Andrew Horne's new treatment going to clinical trial could hugely impact so many women's lives."
Proceedings of the National Academy of Sciences
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